Chronic stress caused by maternal separation is a possible risk factor for the development of 7,12-dimethyl benzo anthracene-induced breast tumors in rats.

BACKGROUND: Chronic stress has been investigated as a risk factor for breast cancer. Maternal separation (MS) of rats has been used as a chronic stress model that alters certain systemic functions, such as the immune response. OBJECTIVE: The aim of this study was to determine the possible effect of MS on the development of breast tumors induced by 7,12-dimethyl benzo anthracene (DMBA). METHODOLOGY: postnatal day (PND) 1 female Wistar rats were divided into four experimental groups that either were or were not subjected to MS and either received or did not receive DMBA. For MS, PND 1 to 21 pups were separated from their mothers for 360 min/day. On PND 30, carcinomas were induced in mammary glands using DMBA. Body weight was evaluated, and the injected region was palpated. In addition, the mammary glands were subjected to histological examination, and corticosterone levels were determined in all groups. RESULTS: DMBA-induced groups had significantly lower body weight gain compared with the non-DMBA-induced groups. Maternal separation increased the incidence of preneoplastic changes and breast carcinogenesis in DMBA-treated animals compared with control animals. Corticosterone levels were increased in both DMBA-induced and MS groups without interaction. CONCLUSION: MS is a possible risk factor for DMBA-induced preneoplastic changes and breast tumors in rats.

La actividad física regula la ingesta de bebidas azucaradas y la velocidad al comer en adultos jóvenes de una institución de educación superior en Bogotá-Colombia / Physical activity regulates the intake of sugar added beverages and the eating speed in young adults from a higher education institution in Bogotá-Colombia

Introducción: El exceso de peso es un problema creciente a nivel mundial, como parte de los factores de riesgo identificados se encuentran dos conductas relacionadas con el con-sumo de alimentos: la ingesta de bebidas azucaradas y la velocidad al comer. Por su parte, la actividad física se ha propuesto como una estrategia útil para la prevención y tratamiento del exceso de peso y comorbilidades asociadas. Objetivo: Identificar la relación de la actividad física con la ingesta de bebidas azucaradas y la velocidad al comer en adultos jóvenes. Métodos: Se realizó un estudio transversal analítico con243 estudiantes de una Universidad de Bogotá, en edades comprendidas entre 18 a 29 años. Se utilizó el cuestionario International Physical Activity Questionnaire (IPAQ) para la actividad física, así como preguntas sobre la frecuencia de ingesta de bebidas azucaradas y la velocidad al comer. Resultados: Se encontró una correlación inversa leve entre la duración de la actividad física diaria y la frecuencia de consumo de bebidas azucaradas, especialmente en el sexo masculino; así mismo, la frecuencia semanal de actividad física vigorosa se relacionó con menor frecuencia de ingesta de bebidas azucaradas. Adicionalmente, se evidenció que la menor duración de la actividad física moderada o vigorosa se relacionó con menor velocidad al comer. Conclusiones: Esta investigación presenta evidencia del papel de la actividad física sobre conductas de riesgo relacionadas con el exceso de peso, se necesita más investigación en el área para fortalecer estos hallazgos. (AU)

Introduction: Excess weight is a growing problem worldwide, as part of the identified risk factors are two behaviors related to food consumption: the intake of sugar added beverages and eating speed. For its part, physical activity has been proposed as an useful strategy for the prevention and treatment of excess weight and associated comorbidities. Objective: To identify the relationship of physical activity with the intake of sugar added beverages and the eating speed in young adults. Methods: An analytical cross-sectional study with 243 students from an University of Bogota, aged between 18 to 29 years. The International Physical Activity Questionnaire (IPAQ) was used for the physical activity assessment, questions about the frequency of sugar added beverages intake and eating speed. Results: A slight inverse correlation was found between the duration of daily physical activity and the frequency of consumption of sugar added beverages, especially in males; Likewise, the weekly frequency of vigorous physical activity was related to a lower frequency of intake of sugar added beverages. Additionally, it was evidenced that the shorter duration of moderate or vigorous physical activity was related to lower speed when eating. Conclusions: This research presents evidence on the role of physical activity on risk behaviors related to excess weight, more research is needed in the area to strengthen these findings. (AU)